Abstract: As a large central city of Northeast China, Changchun is in the key period of industrial transformation. Firstly, this paper deals with the spatial structure of Changchun's industries, and puts forward that the spatial structure has gone through four stages in different historical periods; Secondly, it analyzes the spatial structure characteristics of Changchun's industries, and points out that the industries are in circle structures of distribution as a whole, through spatial expansion; Finally, it gives out the basic strategies of regulating and optimizing spatial structure under the background of accelerating industrialization and urbanization, i.e. in accordance with demanding as a modern international large city, Changchun should break through the existing mode of industrial spaces, adopt the pattern of park agglomeration according to organic dispersing principle, form a new industrial spatial allocation in which the main-city, sub-city (new city), groups, and key central towns are relatively independent, orderly ranked, stressing on main points, in order to assure Changchun's sustainable development.