Abstract: Despotic government on culture and ideological matters was shared among all types of dictatorships around the world. As one typical product of this philosophy of governance, Literary Inquisition deserves special attention within cultural geography scholarship. This research tries to approach the issue of Literary Inquisition from the perspective of regional differentiation, with solid empirical evidence from Shun-Kang-Yong-Qian period of the Qing Dynasty. The research finds that regional cultural backgrounds, local economic conditions and politics were the key determinants that gave rise to the regional differentiation of Literary Inquisition cases, specifically, these determinants included the concentration of literati, educational status of population, social environment, political events, personalities of the governors, ways of governing and political status. Generally, this study tried to cast light on the cultural autocratic governing in ancient China from the geographic perspective which was largely ignored by historians and sociologists. It is an valuable endeavor for its attempt in contributing to a deepened understanding of the issue of Literal Inquisition, and it also provides an enlightening lesson for the construction of a liberal cultural realm at present time.