Three Gorges Reservoir is the biggest one of water conservancy and control projects in the world. After the accomplishment of Three Gorges Reservoir, a 30-m high water-level-fluctuating zone(WLFZ) with an area of 348.93 km² will appear along the both banks. On the one hand, the zone will be of special value for developing diversified economy because there are varied types of landforms and soils; even more there will be not only a land of about 348.93 km² for a considerable period (more than 120 day) of time in a year, but also a better matching relation between precipitation and heat in Summer. On the other hand, the eco-environment of the zone is very fragile, where utilization may induce some environmental problems which affect eco-environment safety of the Three Gorges Reservoir. So the authors, from the development and protection plan of WLFZ, land rights and interests management, the optimum ways of land utilization, forecast and controlling measurements of ecological-risk, etc., suggested some matters and proposals for exploring and protecting of WLFZ. It will provide scientific basis for the planning and development of WLFZ of Three Gorges Reservoir.