Improving and narrowing regional difference is an important task of geography. Regional integration is an efficient approach to improving and narrowing the regional difference. Taking the Zhujiang River delta and its surrounding area as an example, with the analysis of the basis of integration, condition of integration, forces and causes of integration, the paper puts forward the integrated models of these two regions. The study shows, the Zhujing River delta and surrounding region link in physical geography, mutually influencing profoundly in history and territorially connecting together and laying the under of core-peripheral model in southern China, and they have good complementary in resources, industry and commodities. Their accessibility has improved tremendously and economic strength increased hundred times since reforming and opening to outside world for 20 years, they have already had good conditions and basis of integration. In order to realize integrated development, the two regions should emphasized multi-layers dynamics in regional integration which include market forces and government forces, polarization effect and diffusion effect, regional policies, transportation, urban system, industry, etc. taking the emphasis of regional efficiency, sustainability and giving consideration to regional equality as integrated object, they should carry out five models: water valley development model; point-axis development model; regional matching development model; industrial transfer, complements and division model; regional division model as well as the model of network radiation of central cities and making breakthrough from fringe cities.