The sustainable development of human environment system of typical case in the rapid economic development area in central coast area of Guangdong was studied. The dynamic characteristics were described and the running condition of human-environment system was assessed. Using the theories and methods of gray ssytem and Fuzzy mathematics, this paper puts forward a relatively simple and operable synthetical assessment index system and method of sustainable development of human-environment system. The assessment results show that the state of sustainable development of human environment system rose gradually from 1980 to 1990, but descended after 1990 in Shenzhen City and rose gradually from 1980 to update in Dongguan City. The human-environment system both in Shenzhen and Dongguan are weak in the state of sustainable development recently, but that in Dongguan is slightly better than in Shenzhen. The descent cause of sustainable development state of human-environment system in Shenzhen is that the environmental quality became worse and the consuming rate of natural resources was too fast. According to the running pattern of human-environment system in rapid economic development area, two models are suggested:(1) the SEREN model under the condition that human-environment system is not adjust-controlled effectively, and (2) the SEREN model under the condition that human environment is adjust-controlled rationally. The recommendation for sustainnable development of hunan environment system in Shenzhen and Dongguan are also proposed.