Nanhui Area has been as the main part of the great Pudong Area in historical period. Under the condition of the land-forming and economy-changing process, it is the basic characteristic that the spatial administrative system separates from the spatial economic pattern. In the next construction layout of the great Pudong Area, Nanhui Area is standing on a central location. It's developing level of society and economy will effect the development of Pudong even Shanghai and Changjiang Delta. This paper, on a long time perspective, showes the inner nature of the administrative region evolution and the root of irrational status. Conclusion is that fully regarding historical orderliness and modifying the regionization to fit the new economic location based on the thought from spontaneity to selfhood. This conclusion has an important meaning and value to theory and practice in the reform of local administrative region.