Based on the site data and rent attribute data of 1037 office buildings in Beijing City surveyed in July,2009, this paper used the spatial autocorrelation and ordinary Kriging methods to study the relationship between rent and economic spatial structures. Specially, this study tries to investigate the trend of unknown office rent according to the known office rent. The results could be concluded as the following. First, the spatial distribution pattern of office rent presents concentric ring, and coincident with the spatial distribution pattern of standard land price in Beijing. To some extends, these patterns reflex the characteristics of Beijing's urban economic spatial structure, and generally show a concentric ring to the center concentration and along trunk roads and radial roads outside the extension. Meanwhile, there are obvious spatial differences in the city. Second, High-High pattern of office rent spatial distribution is mainly in the office gathering area and near the trunk road and the situation becomes apparent in the concentration distribution, which description Beijing office space to the current trend continues to gather mainly to the heart, location and traffic conditions are important factors affecting office rents. At the same time, office space for rent shows significantly different bias. High-High patterns spot areas chiefly cluster in the northern city of Beijing, and Low-Low patterns spot areas chiefly cluster in the southern city of Beijing, which reveal the internal economic structure of Beijing City is still a significant imbalance. Third, historical inertia, planning guide and events promotion are the principal reasons for leading to the formation and development of the office activities of urban economic spatial structure in Beijing City. And transportation and location conditions also are the main reasons for the formation and development of the office activities of urban economic spatial structure in Beijing City. Therefore, rent is both the main factor of location selection of the office activities and the important index about weighting land-value and economic development degree, and affects indirectly the structure of urban economic space within the formation and development. According to the Kriging method, drawing the unknown office buildings rent distribution trend from the existing office buildings rent, Datun area, Jiangtai area, Cuigezhuang and Dongba area maybe the new higher office buildings rent areas. Spatial analysis method brings the "location" into the rent study, a kind of economic phenomenon, which will help us to get deeper insight into the problem of urban economic spatial structure and find the better targeting possibilities for planning and policy-makers.