Based on fused images of both SPOT and TM in 2008 in central Jiangsu Province as the major data sources, the delineation, water, roads, and other spatial information of rural settlements in the research area are achieved via man-machine interactive interpretation. By the spatial analysis and cluster analysis techniques, grids as the cells, the distribution patterns of rural settlements in central Jiangsu are analyzed, and the categories of rural settlements are classified. The results indicate that: (1) The density of rural settlements in the research area is high in the east and west, lower in the center. However, land-use scale in settlements presents an opposite pattern. (2) The rural settlements that have a high complexity in shape and high degree of fragmentation are located in the south of Taizhou area and in Nantong coastal areas. However, the complexity and fragmentation in the south-central region of Yangzhou, north Taizhou, central, west and south Nantong rural settlements are very small. (3) The differentiation characteristic of the mean nearest neighbor distance is that the rural settlements have a longer distance in the middle of research area, which it indicates that the settlement distribution is sparser and more scattered, the distance of the settlements in the south and east is more nearer, and the distribution of settlements is very concentrated. The distance of the mean nearest neighbor water of the settlements in Nantong area is very small in the southeast settlements, large in the west. The distance of the mean nearest neighbor water of the settlements in Yangzhou area is very small in the west, large in the east. The average spatial distribution pattern of the mean nearest neighbor road of the settlements is unapparent. But the average distance of the most settlements from the roads is very small, from which it indicates that it is very convenient for the settlement in the areas to have internal and external contacts. (4) Finally, by means of establishing the measurement index system of the rural settlements, adopting the method of hierarchical cluster, and combining with the patterns of rural settlements, the rural settlements of central Jiangsu province are divided into three types: Lixiahe lake type, bottomlands along Yangtze River and Yellow Sea type, and central Jiangsu plain type. Lixiahe lake type is low-density cluster-like. Bottomlands along Yangtze River and Yellow Sea type can be divided into two sub-types, such as medium-density arc-belt type and high-density stripe type. Central Jiangsu plain can be divided into 3 sub-types, such as low-density mass type, medium-density broad-band type, and high-density point-scattered type.