Inter-urban linkage is traditional research field of urban geography. With the increasing importance of innovation in city, inter-urban linkage of innovation has aroused the interesting of numerous sholars, some of which have examined the field through direct surveyed approach by co-author published papers or co-author patents granted, however, this approach is limited because it lacks data of the inter-urban and the rusults of survey may not present the comprensive inter-urban innovation situation of the cities. Therefore, we employ a indrect approach , using revised gravity model to map the pattern of inter-urban innovation linkage of Chinese major cities. China takes constructing the innovation country as the core strategy, and urban innovation as the core contents of national innovation system, so urban innovation linkage is an important part of China’s national innovation system. However, a number of issues, such as the current sitation of urban innovaiton linkage, and the pattern and laws of inter urban innovation have rarely been studied. This article will try to study the inter urban innovation linkage among major Chinese cities so as to find innovation source cities and innovation nodes cities in urban innovation system and the general pattern of the inter urban innovation, to promote the complementary and optimization of urban innovation function and to plan the circle of China urban innovation. Based on the review of the literatures of innovation linkage and theoretical analysis, through establishing a set of measureement of index, this article defines ourward innovation linkage of scale and measures innovation linkage and innovation pattern among Chinese major cities. The research shows: 1) the general pattern of urban innovation linkage in East China is stronger and that in West China is weak, and a "Golden Triangle innovation linkage" pattern has formed in the coastal area of China, which takes Shanghai, Nanjing and Hangzhou as the vertex, while Beijing-Tianjin and Guangzhou-Shenzhen as two points. 2) the city innovation linkage presents obvious hierarchy, the cities, such as Beijing, Shanghai, Guangzhou, Shenzhen, Tianjin and Chongqing have national innovation influence with extensive innovative linkage with the other cities in China, while cities, such as Nanjing, Hangzhou, Wuhan, Zhengzhou, Jinan, Qingdao, Dalian and Xi'an have regional innovation influence. 3) in terms of the East Coastal main economic circle in China, the Zhujiang River Delta economic circle has the strongest internal innovation linkage, but less outward innovation radiation; the Changjiang River Delta economic circle has very strong internal innovation linkage with strong external innovation linkage with the cities of Huan Bohai economic circle, while the cities of Beijing, Tianjin and Tangshan have very strong innovation linkage, and with strong outward radiation to the Changjiang River Delta economic circle. This article examines the general innovation linkage pattern among Chinese major cities considering two important elements of distance among cites and scale of urban innovation, but some elements, such institution and policies which may influence the innovation linkage have not been examined, it will be put consideration in future studies.