Taking International Tourism Culture Demonstration Zone of Southern Anhui Province as the object of the study, this article, from the perspective of integrative development of culture and tourism, selecting eighteen UNESCO World Cultural Heritage, UNESCO World Heritage Tentative List and the other well-known cultural resources brands as evaluating indicators, measures the cultural resources abundance of the demonstration zone by establishing the evaluation index system of regional cultural resources abundance. The results of the study are listed as follows: in general, the International Tourism Culture Demonstration Zone of the Southern Anhui Province is quite abundant in its cultural resources, in which Huangshan, Anqing, Xuancheng and Chizhou are the best, which are followed by Maanshan and Wuhui, and Tongling is the worst one in evaluation. The best ones are mostly located in the southern, eastern and western areas of Anhui province. The gap between the southern and the northern Anhui is quite obvious. Viewing from the combination of cultural resources, for its abundant resources brands and huge exploiting potential, Huangshan takes the lead. Xuancheng, Anqing, and Chizhou comes after Huangshan in ranking, possessing a complete type of resources and good exploiting conditions. The combination of resources in Maanshan, Tongling and Wuhu are not satisfied, which are relatively monotonous in types and quite difficult to explore. Therefore, this article suggests that, according to the evaluation results of the cultural resources abundance in this zone, the government and tourism industry should actively explore effective patterns to exploit and use cultural resources, and adopt reasonable exploitation strategies at the same time: Firstly, the combination of regional cultural resources should be greatly promoted. A “hub-and-spoke” system can be built, in which Huangshan acting as a hub to accelerate the development of other cities. Then the transformation of resource assets into industrial advantages can be realized and a complementary regional tourism web can be weaved. Secondly, the selling points of cultural resources and the combination of cultural resources with tourism should be properly seized according to the combination of cultural resources in each city. The differential development of the individual city can be realized by integrating cultural resources into industry, digging the values of cultural resources, strengthening the vivid, cultural and recreational experience of cultural tourism products; Thirdly, while pushing forward protection, non-material cultural resources should be valued and exploited. To maintain its vitality and provide a variety of functions for the design of cultural tourism products, the traditional folk culture should be blended into modern life through the development of tourism; Lastly, a reasonable mechanism and a government-oriented, industry-centered, market-operated and society-involved platform should be established. The inheritance and innovation of demonstration zone’s good cultural resources can be achieved by making policies that support the integration and development of culture and tourism, putting stress on the cultivation of good brands, enhancing the level of information, and improving the quality of services.