Abstract: Developing the Yangtze River and building a developed economic zone along the bank area of the Yangtze River is a great strategic decision of national macroeconomic development distribution. This decision has both given an impetus to fast development of regional economy and exacerbated the problems of economy itself, as well as economy and resources, environment. In this paper, some major problems existing in economic sustainable development, such as scattered industrial structure, duplicated construction of great projects, enlarging developing gap of regional economy and deteriorated environment etc. have been studied. Based on the above analysis, major countermeasures and proposals for increasing the ability of economic sustainable development have been brought out.