Abstract: Plague, a natural focus-based disease closely related to the geographic environment or landscape,is one of the deadly infectious diseases being most harmful to human beings. It is very important to study the geographical epidemic law of plague and distribution of plague nature foci, and analyse their environment-health risk for more effective control of its outbreaks and epidemics. In this paper, 12 natural and social indicators were selected for the purpose of analysing the trend of environmental change and its impacts on plague prevalence, the threshold value of environment-health risk was educed through the clustering analysis and matrix operation of 12 indexes, and 4 different types of environment-health risk area were classified according to the threshold value. The character of low risk area mainly manifested higher rate of forest cover or well developed urbanization where it was unsuitable for dauricus survival anymore. Consequently, the risk of plague prevalence changed into very low possibility. On the contrary, the original surroundings in the very high risky area became deteriorating seriously, and it posed higher probability of plague prevalence. These imply that restoring the environment status in plague foci is the essential way to improve the environment-health risk and control plague prevalence effectively.