Abstract: Occurrence of schools of cetaceans in the Guan River estuary wetland of Jiangsu gave an great and wide impetus to rethink the resources, environment and sustainable development of that region.The Guan River estuary wetland is located on the boundary of Lianyungang and Yancheng in Jiangsu Province.It is rich in natural resources, but constrained by various unfavorable natural conditions and facing human-activity-induced problems, such as baymouth bar limitation, poor infrastructure and harbor facilities, environmental quality degradation, lack of rational development plans, and so on.Landscape eco-planning plays a role in the conservation of biodiversity and environmental improvement.It will not only satisfy the natural functions of landscape and human requirements, but also satisfy the future development.As regard to the future model of natural conservation and resources development, the concept, principle, procedures and main model of landscape eco-planning are introduced.This paper makes a comprehensive survey and summary of the landscape ecological characteristics of the Guan River estuary wetland and proposes some corresponding landscape eco-planning approaches towards sustainable development of the area.The project is composed of some landscape ecological protection areas, and a carefully designed ecological agriculture river-marine farm, ecotourism, planning and framework, harbor and industry estate construction along harbor.