Abstract: This paper discussed the climatic significance of grain-size parameters such as M_z, σ₁, SK₁, Kg, D/SC, the coarse fraction(>63μm) and the clay fraction (<2μm) of 72 samples, which collected from Kekdala section (TKP) in the heart of Takelmukul desert in Yili Valley, Xinjiang. Based on parameters and OSL date data of TKP, five climate evolution stages can be divided since the late Holocene. First stage, from 3.71 kyr BP to 3.06 kyr BP, wind changed from strong to weak, and climate changed from warm-dry to cool-wet. Second stage, from 3.06 kyr BP to 2.78 kyr BP, the grain-size was very coarse, wind was very strong and the climate was warm and dry. Third stage, from 2.78 kyr BP to 2.10 kyr BP, wind was weak, vague soil formed, the climate was wet and little fluctuation. Fourth stage, from 2.10 kyr BP to 0.5 kyr BP, climate was wet, wind was strong-weak alternation and changed frequently in earlier stage; then the wind became weak and climate was cold-wet, and pedogenesis was strong. Last stage, from 0.50 kyr BP to today, the climate was relatively wet as a whole, but wind became stronger and climate was warm-dry in the latest 100 yr. The climate change agreed well with that of global change. Since the late Holocene, due to climatic change of north Atlantic in high latitude, the climate change model of Takelmukul desert has typical westerly characteristics.