Abstract: The Central Place Theory and Economic System Theory have strong theory agreement and mutual feedback. They are both basic theories of Geography and they also have very strong relationship. This mutual feedback of theories reveal in many ways. Firstly, they have strong relationship in conception. From the beginning to the end, region is the most important object of study in the field of Geography. Regional view of Regional Economic Geography determines Economic Region System theory become the most important basic theory of Regional Economic Geography. As a kind of typical economic regional system, the space structure can be seen as the space projection of industrial structure. Secondly, division and relationship are important theory joints on Economic Region System Theory and Central Place Theory. Thirdly, condition analysis take the very important role as basic theory in central place research from the view of economic region. As a very important theoretical basis of the Regional Economic Geography, Economic Region System theory plays an important role on comprehension of Central Place Theory. No matter from concept connotation or from the operating mechanism, it is very clearly that central place system is a part of economic region system. It has the same general attribute of economic region, and it also has many other own characteristics,such as dynamic features, grade features, scale diversity, circle heterogeneity and multi-direction features, overlap and nested structure, re-agglomeration and so on. As a complex economic system, the diffusions of central place system will appear different kind of multi-dimensional-level structures and changes,such as multi-tiered, overlap,bye,enlargement and re-agglomeration.