Abstract: Ecological appraisal of industrial structure and design models of circle economy are two important ways to implement regional sustainable development. Based on the judgment of the phases of industrialization and the characteristics of industrial structure of Shandong Province, according to the relationship among economic benefit, environmental capacity and resources support, the paper set up the model of ecological appraisal of industrial structure. And by analyzing the problems of the existing industrial structure, the paper put forward new ways to adjust it and the corresponding countermeasures under the thoughtfulness of circle economy. It has important guidance functions to push the sustainable development of Shandong Province.