Abstract: Based on the data analysis of materials collected from 785 question-and-answer surveys in Guangdong ,the paper obtains some main characteristic of technology innovation within Small and middle enterprises (SMEs) and regional environment and draws some conclusions as follow: 1) Technology innovative ability of those SMEs in Guangdong has gained a significant improvement, at the same time, innovation output performance such as patent level is pool; 2) Most of the SMEs choose cooperation strategy and simulated strategy as their own technology innovative strategy; 3) Supplied merchant and custom play an important role in innovative network, but high school, research institution and agency service institution have less role; 4) To improve technology and administration level is the main innovative motivation for those SMEs, but the shortage of skilled work force, new technology and law environment is the restricted condition of Guangdong innovative environment ; 5) Most of the SMEs hold optimism attitude for Guangdong Province and think that Zhujiang (Pearl) River Delta is their first choice for industrial investment in future.