With the development of major economic zones (belts) in the three provinces becoming a national strategy and the successive construction of many big infrastructures recently, the economy of Northeast China has been rapidly developed, which obviously accelerates the integration process of Northeast China. Moreover, the improving international environment and increasing cooperation demand remarkably motivate the tourism development of the eastern border area in Northeast China. The eastern border area herein is defined as an area of Northeast China which is close to Russia and North Korea, including territorial ranges of Hegang, Jiamusi, Shuangyashan, Qitaihe, Jixi, Mudanjiang, Yanbian Korean Autonomous Prefecture, Baishan, Tonghua, Benxi, and Dandong. In terms of geographic location, touring resources and historical cultures, the border area definitely plays a leading role in Chinese regional touring cooperation in the northeastern Asia. Touring in the northeastern Asia presently is becoming globally popular, and tourism development will encounter a new breakthrough in regional cooperation of China. Simultaneously, the border area is a main body of Chinese regional cooperation in the northeastern Asia, which bears the reality and feasibility of all-win researching and developing tourism in the international cooperation. The cooperative activities include developing strategies and market strategies of regional tourism, planning and spreading selected touring lines, coordinating foreign negotiation to develop and exploit characteristic touring programs such as border touring and touring abroad, building regional touring network, and establishing market system and business service platform. In this article, based on the detailed investigation and systematic analysis of successful experience of border tourism in China and overseas, the critical issues on cooperative development of tourism in border area are profoundly discussed, aiming to promote the progress of touring chains in the area and the northeastern Asia. Through detailed study of tourism resources advantages, current situation and issues of tourism development, specific suggestions are proposed to regional tourism development of the eastern border area in Northeast China. The developing keys of characteristic touring products is border touring, natural-ecologic touring, ice and snow touring, and culture touring, based on which, the corresponding tourism spatial layout and regional strategic cooperation of “five regions” (i.e., Jiamusi-Fuyuan, Xingkai Lake, Mudanjiang-Suifenhe, Yanji-Changbai Mountains, and Benxi-Yanji touring areas) and “four axes” (i.e., Heilongjiang River, Wusulijiang River, Tumenjiang River, and Yalujiang River touring axes) are also constructed.