Abstract: In the 20th century, the achievement of geo-science was resplendent in China, which established the modern scientific basis. Confronted with chance and challenge to globalization, network and knowledge economy in 21^st century, global study need to be emphasized. The earth's surface between ionosphere and Moho surface is the mean layer of information transmission and the most active human civilization, all of these belong to comprehensive research fields of geo-system science. Progress in the earth observation technology system and advancement of temporal and spatial resolution have made global synchronous dynamic monitoring into reality, information source is very profuse. Networkation has strategically exploited some new research areas, such as "Geo-information science" and "Digital Earth"; which has enhanced our reunderstanding to urbanization, resource, ecology and environment; and strengthened the ability of geographical strategy decision and participating in project programming and planning. Geography is comprehensive subject derived from nature and based on human, which always pays attention to exploit temporal law and spatial structure and it's transformation, geographical science must deeply mine profound geo-information resources, accelerate its informalization and modernization, thus it can fully bring whole and traditional predominance into play. With globalization, network and intelligence together, geo-science must have splendent future in the 21st century.