Abstract: The regionalization of potential development under eco-economic approach is a useful way to zone the region for different intensity on behalf of spatial balance for the harmony of population, economy, resources, and environment. emphasizing the adjusting measures to local conditions can decide some areas with low-cost, large environmental capacity to be encouraged for exploitation of industrialization and urbanization while others need agricultural and ecological conservation. It is not only an important foundation of balanced regional development and harmonious spatial order, but also a basic project for the main function regionalization. Meanwhile it is the demand for the various and characteristic development. Based on such conception and recognition, the essay illustrates how to divide the assessed units, choose and manage the assessed elements, and proposes the method of classification matrix integrated the ecological significant value with economic significant value, therefore divides the region into kinds of area with the help of GIS. Finally, according to the regionalization, the essay discusses the method of main function regionalization and the policy guarantee of controlling the regional space.