Abstract: Based on the main factor influencing the loess collapsibility, the data of collapsibility test on collapsible loess foundation in Zheng-Xi High-Speed Railway are collected and summarized, a model of ANFIS based on the index about the loess collapsibility has been established in this paper. Compared the results with the conclusion by the method of multivariate linear regression, it is shown that the ANFIS prediction model could improve the accuracy of forecasting. The results shows that the prediction result after trained and predicted for the samples is in good agreement with the experimental results, and this method is a relatively optimum method for forecasting, at the same time it provides an important viewpoint to explore the collapsibility law on the loess foundation of high-speed railway.