Abstract: Major transportation facilities projects implemented since 1949 have brought about significant changes in Guangzhou's urban spatial structure and urban form. There are three stages of changes. During the first 30 a after the founding of the People's Republic of China, the government has paid much attention to the construction of the major urban roads and bridges, forming a spatial structure of "stripes of dispersed groups" along the Zhujiang River in Guangzhou. After two decades of reform and openning-up, many efforts have been made to construct urban expressways, resulting in urban expansion along the Zhujiang River and the Baiyun Mountain. The spatial structure of Guangzhou thus changed into an "L" shape comprised of three major groups. During the first decade of the 21st century, Panyu County and Huadu County were merged into Guangzhou metropolis. A series of transportation facilities, such as Baiyun International Airport, South Railway Station of Guangzhou, Nansha Deep-water Port, MTR system lines, were deployed and constructed in the expanded Guangzhou metropolitan area, forming a "multi-center, multi-axis network" spatial structure. During the process, the construction of major transportation facilities has projected significant influences on Guangzhou's urban spatial structure. The road traffic framework first guided urban development into stripes shape, the rapid traffic system then adjusted the urban spatial structure into "L" shape; and large-scale facilities and track transportation facilities fundamentally altered the existing structure into a "multi-center, multi-axis network" in accordance to the spatial organization of the rapid expanding metropolitan area. The emphases of transportation facilities construction varied in different stage of urban developmen. 1) In the growing period of the city, the emphases of transport facilities construction were palced on the infrastructures, such as major urban roads and bridges. 2) During the rapid urban development period, the emphases of transportation facility constructions were rapid traffic system. And 3) in the stable development period, the emphases of transportation facilities are to foster a new growing pole and development axis through constructing regional large-scale facilities and track transportation facilities. By that, the major transportation facility construction and urban spatial structure development form a reciprocal relationship and an effective feedback loop.