为制定中国老年前期男性血红蛋白正常参考值的统一标准提供科学依据,收集了中国186个单位用氰化高铁血红蛋白(HiCN)法测定的22 799例老年前期男性血红蛋白正常参考值,运用相关分析和回归分析的方法,研究了其与地理因素的关系。发现老年前期男性血红蛋白正常参考值与中国地理因素之间有很显著的相关关系。依据血红蛋白正常参考值与地理因素的依赖关系把中国分为青藏区、西南区、西北区、东南区、华北区、东北区等6个区。
This paper aims at supplying a scientific basis for uniting the normal reference value standard of hemoglobin of Chinese presenile men,a research is made about relationship between the reference value of Chinese healthy presenile men's hemoglobin and five geographical factors in 161 areas in China, the normal reference value is determined by the hemoglobincyanide method. The ages of the volunteers range from 46 to 59 years old. It is found that the correlation of geographical factors and the reference value of Chinese presenile men's hemoglobin are quite significant (F=192.81) from the following equation:
Ŷ=150.7+0.005 880 X1-1.452 X4+0.0113 1 X5±17.9
F=192.81
In the above equation, is the normal reference value of presenile men's hemoglobin (g/L); X1 is the altitude (m); X4 is the annual average temperature (℃); X5 is the annual precipitation (mm); 17.9 are the value of the 1.96 residual standard deviations. If geographical values are obtained in some areas, the reference value of Chinese presenile men's hemoglobin of this area can be reckoned using regression equation. For example, in the Beijing area, the altitude is 31.2 m, the annual average temperature is 11.5 ℃, and the annual precipitation is 644.2 mm. By means of the regression equation, the following can be calculated:
Ŷ=150.7+0.005880×31.2-1.452×11.5+0.01131×644.2±17.9=141.5±17.9
So, the calculated normal reference value of presenile men's hemoglobin can be obtained, the normal reference value of presenile men's hemoglobin is 141.5±17.9 g/L. Furthermore, according to the similarity of the reference value of Chinese presenile men's hemoglobin, taking the altitude as the main dividing basis and considering effects of other geographical factors and population distribution, China can be divided into six regions: Qinghai-Xizang, Southwest, Northwest, Southeast, North and Northeast regions.
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